Evaluation of Embryo-larval Toxicity of the Antibiotic Ceftriaxone in the Fish Danio rerio (Zebrafish)

Authors

  • Elias Marques de Oliveira Centro Universitário ICESP, Brasília, DF, Brasil
  • Diego Sousa-Moura Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Brasília, DF, Brazil
  • Cesar Koppe Grisolia Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, UnB, Brasília, DF, Brasil
  • Mariana Furio Franco-Bernardes Laboratório de Genética Toxicológica, Universidade de Brasília (UnB); Centro Universitário ICESP, Brasília, DF, Brazil https://orcid.org/0000-0002-2183-0412

DOI:

https://doi.org/10.5132/eec.2023.02.06

Keywords:

Environment, Ecotoxicology, cephalosporins, Danio rerio

Abstract

Antibiotics comprise a class of pharmaceutical products that have been generating increasing global concern due to their detection in environmental matrices. Cephalosporins constitute the largest group of antibiotics employed for human and animal treatment in most countries. Ceftriaxone belongs to the class of third-generation cephalosporins and can reach the aquatic environment. Studies in the literature have shown the toxic effect of ceftriaxone on zebrafish at high concentrations, and on cyanobacteria at environmental concentrations. The aim of this study was to evaluate the effects of ceftriaxone (0.05 mg/L, 0.5 mg/L, 5.0 mg/L, 50 mg/L and 100 mg/L) on the development of embryos and larvae of zebrafish. The Fish Embryotoxicity Test (FET) was performed according to OECD protocol n. 236. The results showed that the tested concentrations of ceftriaxone did not cause lethal or sublethal effects on zebrafish embryos and larvae. However, considering data in the literature, added to the fact that cephalosporin-class antibiotics are widely used, the use and disposal of ceftriaxone cannot be neglected.

Author Biography

Mariana Furio Franco-Bernardes , Laboratório de Genética Toxicológica, Universidade de Brasília (UnB); Centro Universitário ICESP, Brasília, DF, Brazil

Centro Universitário ICESP, Brasília, DF, Brasil

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Brasília, DF, Brasil

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Published

27-01-2024

How to Cite

Oliveira, E. M. de, Sousa-Moura, D., Grisolia , C. K., & Franco-Bernardes , M. F. (2024). Evaluation of Embryo-larval Toxicity of the Antibiotic Ceftriaxone in the Fish Danio rerio (Zebrafish). Ecotoxicology and Environmental Contamination, 18(2), 40–46. https://doi.org/10.5132/eec.2023.02.06

Issue

Vol. 18 No. 2 (2023)

Section

Original Articles

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