Genotoxicity Evaluation of Commercially Available Acid Red Dye by Comet Assay in Fish (Cyprinus Carpio)
Abstract
Genotoxicity of commercially available acid red dye on fish was evaluated. Fish were exposed to various concentrations of the dye and gill processed for comet assay. Nucleoids were visually scored and categorized into various damage degrees. Significant increase (p < 0.05) in the percentage and distribution of damaged nucleoids was recorded in all dye-treated groups over control. DNA damage scores (AU) increased with exposure concentrations and dose-response was observed at higher doses. From the results it is concluded that commercially available acid red dye is potentially genotoxic to fish. The results are preliminary and further studies are warranted to acknowledge this effect.
Keywords: acid red, commercial dyes, genotoxicity, comet assay.
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